Applications are invited for 11 PhD student positions (“Early Stage Researchers”) to be funded by the Marie-Sklodowska-Curie Innovative Training Network “INTEGRATE – Interdisciplinary Training Network for Validation of Gram-Negative Antibacterial Targets” within the Horizon 2020 Programme of the European Commission. INTEGRATE is a consortium of high profile universities, research institutions and companies located in Italy, Finland, Latvia, United Kingdom, Slovenia, Germany, Belgium and Portugal.
All applications must be submitted through the on-line job application portal. Candidates apply electronically for one to maximum three positions and indicate their preference. Candidates provide all requested information including a detailed CV. During application, applicants will need to prove that they are eligible (three aspects: respect ESR definition, mobility criteria, English language proficiency). The deadline for the on-line registration is 9 March 2015.
Description
The 11 available positions:
ESR 1. Design, synthesis and optimization of inhibitors of enzymes involved in the sulfur assimilation pathway in Gram-negative bacteria
ESR 2. Characterization of S. typhimurium sulfur assimilation targets SAT and OASS
ESR 3. Systematic bioactivity evaluation of potential antibacterial agents in vitro: From biosensor-based HTS to follow-up studies
ESR 4. Computer-aided drug design, hit finding and optimization
ESR 5. Design and synthesis of mechanism based O-acetylserine sulfhydrylase inhibitors
ESR 6. The glyoxylate shunt as a target for antibacterial intervention in Gram-negative bacteria
ESR 7. Discovery of novel gyrase B and gyrase B/topoisomerase IV (ParE) dual inhibitors with in vitro antibacterial activity
ESR 8. E. coli LsrK Kinase Inhibitors as Quorum Sensing interfering agents: validation of therapeutic potential
ESR 9. Identification of novel covalent ClpP inhibitors as inhibitors of gram-negative bacteria
ESR 10. Design, synthesis and characterization of novel modulators of ClpP proteases from Gram-negative bacteria
ESR 11. In vitro characterization and in vivo efficacy evaluation of selected compounds against relevant biofilm-producing Gram-positive and Gram-negative pathogens
• You have a master degree, preferentially in pharmaceutical sciences, microbiology, biochemistry or molecular biology
• You have a true research spirit and you enjoy problem solving
• You are highly motivated to work in a multidisciplinary team
• You have excellent organizational and communication skills and you are prepared to work under strict timelines
• You will write project reports for your supervisor on a regular basis
• You will be working within our international group of 25 researchers
• You will get in contact with the other members of this international consortium and will benefit from the training platform
• You have a true research spirit and you enjoy problem solving
• You are highly motivated to work in a multidisciplinary team
• You have excellent organizational and communication skills and you are prepared to work under strict timelines
For more details, full job descriptions, and online application, please visit our website:
http://www.cdr.fi/news-and-events/integrate-etn-job-announcement
Nr of positions available : 11
Research Fields
Chemistry – Biochemistry
Career Stage
Early stage researcher or 0-4 yrs (Post graduate)
Research Profiles
First Stage Researcher (R1)
Benefits
The MSCA programme offers highly competitive and attractive salary and working conditions. The successful candidates will receive a salary in accordance with the MSCA regulations for early stage researchers. Exact salary will be confirmed upon appointment [Living allowance = approximately 37.320 euro/year (depending on a correction factor to be applied per country) + Monthly mobility and family allowance = 600 or 1100 euro depending on the family situation]. In addition to their individual scientific projects, all fellows will benefit from further continuing education, which includes internships and secondments, a variety of training modules as well as transferable skills courses and active participation in workshops and conferences.
Comment/web site for additional job details
For detailed ESR project descriptions and access to the online application portal, please see website:
http://www.cdr.fi/news-and-events/integrate-etn-job-announcement